3,3-二{2,2-二[4-(N,N-二取代氨基)苯基]乙烯基}-4,5,6,7-四氯-2-苯并[c]呋喃酮的合成 |
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引用本文: | 王清文,孙才英,隋淑娟,刘志明,张学明,刘彦春.3,3-二{2,2-二[4-(N,N-二取代氨基)苯基]乙烯基}-4,5,6,7-四氯-2-苯并[c]呋喃酮的合成[J].有机化学,1998,18(2):175-179. |
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作者姓名: | 王清文 孙才英 隋淑娟 刘志明 张学明 刘彦春 |
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作者单位: | 东北林业大学化学系 |
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摘 要: | 在对甲苯磺酸存在下,采用1,1-二4-(N,N-二取代氨基)苯基]乙烯(3)和四氯苯酐在乙酸酐溶液中的缩合反应合成了3,3-二{2,2-二4-(N,N-二取代氨基)苯基]乙烯基}-4,5,6,7-四氯-2-苯并c]呋喃酮(4),产率89~93%。3由4,4'-二(N,N-二取代氨基)二苯甲酮(1)与甲基碘化镁进行Grignard反应的产物经水解再脱水制得,产率85%~88.5%(以1为基准)。
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关 键 词: | 对甲苯磺酸 呋喃酮 P 缩合反应 有机合成 苯酐 P 苯乙烯 P 苯并呋喃 P 苯乙烯基 格氏反应 四氯苯 P |
Synthesis of 3,3-bis[1,1-bis(4-disubstituted aminophenyl) ethylen-2-yl]-4,5,6,7-tetrachlorophthalides |
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Abstract: | 3,3-Bis1,1-bis(4-disubstituted aminophenyl)ethylen-2-yl]- 4,5,6,7-tetrachlorophthalides (4) were synthesized by the condensation of tetrachlorophthalic anhydride with 1,1-bis4- disubstituted aminophenyl)ethylenes (3) in acetic anhydride in the presence of p-toluene-sulfonic acid, yields 89%~93%. Compound 3 were prepared by the dehydration of 1,1-bis(4- disubstituted aminophenyl)ethanols (2) which were synthesized by Grignard reaction of 4,4'-bis(N,N-disubstituted amino) benzophenones (1) with methyl magnesium iodide, yields 85%~88.5% (based on 1). |
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Keywords: | P-METHYLBENZENESULFONIC FURANONE P CONDENSATION REACTION ORGANIC SYNTHESIS PHTHALIC ANHYDRIDE P STYRENE P BENZOFURAN P STYRYL GROUP GRIGNARD REACTION TETRACHLOROBENZENE P |
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