| 含磺酰胺基和羧苯基的异方酰胺的合成 |
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| 引用本文： | 李聚才,周海兵,陈益钊. 含磺酰胺基和羧苯基的异方酰胺的合成[J]. 有机化学, 1998, 18(4): 337-341 |
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| 作者姓名： | 李聚才 周海兵 陈益钊 |
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| 作者单位： | 四川大学化学系，四川大学化学系，四川大学化学系 成都 610064，成都 610064，成都 610064 |
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| 摘 要： | 以3-[邻(或对)羧苯胺基]-4-羟基-3-环丁烯二酮(1a, 1b)为底物,与一些磺胺反应, 成功地制得了14个新的不对称取代的异方酰胺。3a～3f和4a～4f结构上的共同特点是, 有药物作用的磺酰胺和邻(或对)氨基苯甲酸的结构单元, 通过方酸四碳环的桥接作用而共存于同一分子之中。
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| 关 键 词： | 合成 苯胺 P 苯甲酸 P 氨基化物 酮 P 磺酰胺 P 环丁烯 P 芳香族胺 方酸 异方酰胺 |
Synthesis of isosqurarylium amides containing N''-substituted sufamoyl phenyl and carboxy phenyl groups |
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| LI Ju - Cai ZHOU Hai - Bing CHEN Yi - Zhao. Synthesis of isosqurarylium amides containing N''-substituted sufamoyl phenyl and carboxy phenyl groups[J]. Chinese Journal of Organic Chemistry, 1998, 18(4): 337-341 |
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| Authors: | LI Ju - Cai ZHOU Hai - Bing CHEN Yi - Zhao |
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| Abstract: | Fourteen new asymmetric substituted isosqurarylium amides were successfully obtained by the reaction of 3 - [ ortho - (or para - ) carboxy anilino] - 4 - hydroxy - 3 - cyclo - butenedione with some sulfanilamides. The common marked characteristic of the structure of these compounds 3a - 3f and 4a - 4f is that the structure units with medicinal effective sulfanilamide and ortho - (or para - ) benzaminic acid existed in the same molecule through the bridging of the tetracarbon ring of squaric acid. |
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| Keywords: | sulfanilamide benzaminic acid isosqurarylium amide cyclobutenedione chemistry of squaric acid |
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