一维多重接力COSY和选择性远程DEPT核磁共振技术在新分子骨架生物碱结构测定和谱峰归属研究中的应用

自防已科千金藤根中分得一个新型分子骨架的四氢异喹啉类生物碱-excentricine(1)。本工作采用一维多重接力COSY和选择性远程DEPT核磁共振新技术成功地确定谱峰归属, 鉴别和连结被季碳和杂原子分割开的自旋体系, 测定了其结构。

Structural determination and spectral assignment of an alkaloid with a novel skeleton by selective long-range DEPT and 1D multiple relay COSY NMR techniques

A novel skeleton alkaloid, excentricine, was isolated from the roots of stephaniaexcentrica. The recent introduced selective long-range DEPT and 1D multiple relay COSY NMR techniques have been successfully used to identify and to connect spin systems separated by quaternary carbons and heterotoms and total assignment of 1H and 13C NMR spectra were achived. Its structure has been elucidated as 1.