Using dextromethorphan potentiometric membrane sensor in analysis of dextromethorphan hydrobromide in pharmaceutical formulation and urine; Computational study |
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| Authors: | M R Ganjali B Larijani H Shams S Riahi F Faridbod P Norouzi |
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| Institution: | 1.Center of Excellence in Electrochemistry, Faculty of Chemistry,University of Tehran,Tehran,Iran;2.Endocrinology & Metabolism Research Center,Tehran University of Medical Sciences,Tehran,Iran;3.Department of Chemistry,Islamic Azad University of Shahreray Branch,Shahreray,Iran;4.Institute of Petroleum Engineering, Faculty of Engineering,University of Tehran,Tehran,Iran |
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| Abstract: | Dextromethorphan (DXM) is an antitussive (cough Hyj/UA suppressant) drug found in many cough medicines. Dextromethorphan has also found other uses
in medicine, ranging from pain relief to psychoactive applications. In this study, a potentiometric liquid membrane sensor
for simple and fast determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine was constructed.
For the membrane preparation, DXM-tetraphenylborate complexes were employed as electroactive materials in the membrane. The
wide linear range (10−6–10−2 M), low detection limit (1 × 10−6 M), and fast response time (∼5 s) characterize the proposed sensors. Validation of the method shows suitability of the sensors
for applications in the determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine. |
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