Electrothermal vaporization dynamic reaction cell inductively coupled plasma mass spectrometry for the determination of Fe,Co, Ni,Cu, and Zn in biological samples |
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Authors: | Yen-Jia Tseng Yu-Duan Tsai Shiuh-Jen Jiang |
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Institution: | (1) Department of Chemistry, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan |
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Abstract: | Slurry sampling electrothermal vaporization dynamic reaction cell inductively coupled plasma mass spectrometry (ETV-DRC-ICP-MS)
has been applied to determine Fe, Co, Ni, Cu, and Zn in biological samples. The influences of instrument operating conditions
and slurry preparation on the ion signals were reported. Pd was used as the modifier. The effectiveness of the ETV sample
introduction technique and dynamic reaction cell in alleviating various spectral interferences in ICP-MS analysis has been
demonstrated. This method has been applied to determine Fe, Co, Ni, Cu, and Zn in NIST SRM 1573a tomato leaves reference material
and NRCC DORM-2 dogfish muscle reference material and also real samples such as a tea and a swordfish sample purchased locally.
Since the sensitivities of the elements studied in slurry and aqueous solution were different, an analyte addition technique
was used for the determinations. The analytical results of the reference materials agreed with the certified values. The precision
between sample replicates was better than 6% for all determinations. The method detection limit estimated from analyte addition
curves was 0.01, 0.006, 0.007, 0.004, and 0.006 μg g−1 for Fe, Co, Ni, Cu, and Zn, respectively, in the original biological samples. |
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Keywords: | Dynamic reaction cell inductively coupled plasma mass spectrometry Slurry sampling Electrothermal vaporization Biological samples Fe Co Ni Cu and Zn |
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