Rosa Damascena mediated ZnO-Red Ochre nanocomposite for the electrochemical determination of 5-Fluorouracil |
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Institution: | 1. Alumni Association of Sharif University of Technology, 11365-11155 Tehran, Iran;2. Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, 82030, San Salvatore Telesino, BN, Italy;3. Nutringredientes Research Center, Federal Institute of Education, Science and Technology (IFCE), Brazil;4. Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, Iran;5. Anesthesia Techniques Department, Al-Mustaqbal University College, Babylon, Iraq;6. Institute of Nano Science and Nano Technology, University of Kashan, Kashan 87317-51167, Iran |
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Abstract: | In this study, ZnO-Red Ochre nanocomposite was green synthesized by Rosa Damascena (RD) extract (RDZRONCs). Proton Induced X-ray Emission microanalysis (Micro-PIXE) and X-ray diffraction (XRD) pattern confirmed the presence of hematite (Fe2O3), and quartz (SiO2) mineral phases in the Red Ochre (RO) nanoclay. In addition, the XRD pattern shows the ZnO, ZnFe2O4, SiO2, Fe2O3, and Si phases in the RDZRONCs that were green synthesized with natural RD extract and RO. The RDZRONCs were used to modify the carbon paste electrode (CPE) for the electrochemical determination of the anticancer drug 5-fluorouracil (5-FU). Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques were employed to investigate the surface behavior of modified CPE (RDZRONCs/CPE). The electrochemical behavior of 5-FU at the RDZRONCs/CPE was exanimated by CV, differential pulse voltammetry (DPV), chronoamperometry (CA), and chronocoulometry (CC). Based on the DPV technique, a linear relationship between peak current and concentration of 5-FU was obtained in the dynamic range of 0.05–140.0 μM and with a detection limit equal to 0.0016 μM. The selectivity of RDZRONCs/CPE for 5-FU was studied in the presence of different inorganic and organic species. Also, the content of 5-FU was measured in real samples by RDZRONCs/CPE. |
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Keywords: | Green synthesis Nanoclay 5-Fluorouracil Electrochemical sensor |
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