|
|||||
|
|
Synthesis of the antimalarial drug FR900098 utilizing the nitroso-ene reaction |
|
| Authors: | Fokin Andrey A Yurchenko Alexander G Rodionov Vladimir N Gunchenko Pavel A Yurchenko Raisa I Reichenberg Armin Wiesner Jochen Hintz Martin Jomaa Hassan Schreiner Peter R |
| Affiliation: | Department of Organic Chemistry, Kiev Polytechnic Institute, pr. Pobedy 37, 03056 Kiev, Ukraine. aaf@xtf.ntu-kpi.kiev.ua |
| Abstract: | The antimalarial drug FR900098 was prepared from diethyl allylphosphonate involving the nitroso-ene reaction with nitrosocarbonyl methane as the key step followed by hydrogenation and dealkylation. The utilization of dibenzyl allylphosphonate as the starting compound allows one-step hydrogenation with dealkylation, which simplifies the preparative scheme further. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |