DBU-promoted alkylation of alkyl phosphinates and H-phosphonates |
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Authors: | Laurent GavaraChristelle Petit Jean-Luc Montchamp |
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Affiliation: | Department of Chemistry, Box 298860, Texas Christian University, Fort Worth, Texas 76129, United States |
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Abstract: | The alkylation of alkyl phosphinates and some H-phosphonate diesters is promoted by the base DBU. Only more reactive alkyl halides react in preparatively useful yields. However, the method provides easy access to important H-phosphinate building blocks, without the need for a protecting group strategy or metal catalysts. The reaction is conveniently conducted at, or below, room temperature. The preparation of methyl-H-phosphinate esters is particularly interesting as it avoids the heretofore more common use of methyldichlorophosphine MePCl2. |
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Keywords: | Alkylation H-Phosphinate H-Phosphonates DBU |
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