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Synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via a Pictet-Spengler approach |
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| Authors: | Rikard LarssonNarda Blanco Martin JohanssonOlov Sterner |
| Institution: | Centre for Analysis and Synthesis, Lund University, PO Box 124, SE 22100, Sweden |
| Abstract: | A protocol for the diastereoselective synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via Pictet-Spengler condensation with L-DOPA or l-DOPA derivatives and 1H-indole-3-carbaldehydes is presented. The protocol is used for the successful synthesis of several tetrahydroisoquinolines as well as diketopiperazine fused analogues. |
| Keywords: | Pictet-Spengler condensation l-DOPA" target="_blank">l-DOPA 1H-Indole-3-carbaldehydes C-1 Indolyl tetrahydroisoquinolines Diketopiperazine fused tetrahydroisoquinolines |
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