Cu(I)-catalyzed enantioselective [3 + 2] cycloaddition reaction of 1-alkylallenylsilane with alpha-imino ester: asymmetric synthesis of dehydroproline derivatives |
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| Authors: | Daidouji Kazunori Fuchibe Kohei Akiyama Takahiko |
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| Affiliation: | Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan. |
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| Abstract: | [reaction: see text] The catalytic, enantioselective [3 + 2] cycloaddition reaction of 1-alkyl-substituted allenylsilanes with alpha-imino ester has been achieved by means of [Cu(MeCN)(4)]BF(4)/(R)-DM-SEGPHOS catalyst to afford silyl-substituted dehydroproline derivatives in high yields and enantioselectivities. |
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