UV-INDUCED REVERSION OF ADENOVIRUS 5ts2 INFECTING HUMAN CELLS |
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| Authors: | Rufus S Day III Chuck H J Ziolkowski |
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| Institution: | Bldg. 37, Rm. 3C23, Nucleic Acids Section, LMC, DCCP, NCI, NIH, Bethesda, MD 20205, USA |
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| Abstract: | Abstract— Among the progeny produced by UV-irradiated adenovirus 5ts2 when infecting either A498 (human kidney tumor) or CRL1187 (normal human fibroblast) strains at 32° C were a certain number (UV–fluence dependent) of revertants able to grow at 39° C. Within experimental error, the induced reversion frequency was independent of whether or not the cells received UV (5 J/m2) 20 h prior to infection, indicating that induced error-prone repair was not observed in these experiments. |
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