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Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity |
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| Authors: | Frolova Liliya V Malik Indranil Uglinskii Pavel Y Rogelj Snezna Kornienko Alexander Magedov Igor V |
| Institution: | a Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA b Department of Biology, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA c Department of Organic Chemistry, Timiryazev Agriculture Academy, Moscow 127550, Russia |
| Abstract: | A multicomponent reaction of 3-aminopyrazol-5-ones with substituted salicylic aldehydes and acetylacetic ester leading to the formation of novel 2,3-dihydrochromeno4,3-d]pyrazolo3,4-b]pyridine-1,6-diones was discovered. The elucidation of the reaction scope revealed that 5-aminopyrazoles, 3-amino-1,2,4-triazoles and 6-aminouracil could be used as the heterocyclic amine component. Selected heterocyclic products were found to possess notable antibacterial activities. |
| Keywords: | MCR Aminopyrazole Antibacterial activity Benzopyranopyridines |
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