Human Enzymes for Organic Synthesis |
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| Authors: | Dr Margit Winkler Dr Martina Geier Dr Steven P Hanlon Prof?Dr Bernd Nidetzky Prof?Dr Anton Glieder |
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| Institution: | 1. Institute for Molecular Biotechnology, Graz University of Technology, Graz, Austria;2. acib GmbH, Graz, Austria;3. F. Hoffmann-La Roche, Basel, Switzerland;4. Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Graz, Austria |
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| Abstract: | Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites. |
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| Keywords: | biocatalysis biotransformation drug metabolites human enzymes pharmaceutical compounds |
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