1,4‐Iron Migration for Expedient Allene Annulations through Iron‐Catalyzed C−H/N−H/C−O/C−H Functionalizations |
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Authors: | Jiayu Mo Thomas Müller Dr João C A Oliveira Prof?Dr Lutz Ackermann |
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Institution: | 1. http://www.ackermann.chemie.uni‐goettingen.de/;2. Institut für Organische und Biomolekulare Chemie, Georg-August-Universit?t G?ttingen, G?ttingen, Germany |
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Abstract: | C?H activation bears great potential for enabling sustainable molecular syntheses in a step‐ and atom‐economical manner, with major advances having been realized with precious 4d and 5d transition metals. In contrast, we employed earth abundant, nontoxic iron catalysts for versatile allene annulations through a unique C?H/N?H/C?O/C?H functionalization sequence. The powerful iron catalysis occurred under external‐oxidant‐free conditions even at room temperature, while detailed mechanistic studies revealed an unprecedented 1,4‐iron migration regime for facile C?H activations. |
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Keywords: | allenes C− H activation iron migration redox-neutral reactions |
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