Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy |
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| Authors: | Dr. Jingchao Li Dr. Chen Xie Dr. Jiaguo Huang Yuyan Jiang Dr. Qingqing Miao Prof. Kanyi Pu |
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| Affiliation: | School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore |
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| Abstract: | Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near‐infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5‐fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy. |
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| Keywords: | cancer therapy photothermal therapy polymer nanoparticles protein activity |
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