Palladium‐Catalyzed para‐Selective Alkylation of Electron‐Deficient Arenes |
| |
| Authors: | Dr Zhiwei Jiao Dr Li Hui Lim Prof Dr Hajime Hirao Prof Dr Jianrong Steve Zhou |
| |
| Institution: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore;2. Department of Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China |
| |
| Abstract: | Intermolecular alkylations of electron‐deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical Friedel–Crafts alkylations, which prefer electron‐rich systems. |
| |
| Keywords: | alkyl radicals alkylation arenes palladium catalysis synthetic methods |
|
|
