Redox‐Divergent Synthesis of Fluoroalkylated Pyridines and 2‐Pyridones through Cu‐Catalyzed N−O Cleavage of Oxime Acetates |
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| Authors: | Dr. Dachang Bai Xueli Wang Dr. Guangfan Zheng Prof. Dr. Xingwei Li |
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| Affiliation: | 1. Henan Key Laboratory of Organic Functional Molecules and Drugs Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China;2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China |
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| Abstract: | Cu‐catalyzed redox‐divergent [3+3] coupling of oxime esters with β‐CF3 enones and acrylates is described. This redox‐neutral coupling with enones and acrylates affords trifluoromethylated pyridines and pyridones, respectively. Under reductive conditions, difluoromethylated pyridines, difluoromethlated pyridones, and trifluoromethylated dihydropyridones are obtained. The reactions occur under mild conditions with broad substrate scope and regio/redox selectivity. |
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| Keywords: | copper fluoroalkylation oximes pyridines pyridones |
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