Cascade Claisen Rearrangement: Rapid Synthesis of Polysubstituted Salicylaldehydes and Total Syntheses of Hemigossypol and Gossypol |
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| Authors: | Tongxiang Cao Yi Kong Kui Luo Dr Lianfen Chen Prof Shifa Zhu |
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| Institution: | School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China |
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| Abstract: | A cascade Claisen rearrangement of a well‐organized maltol propargyl ether for the construction of polysubstituted salicylaldehydes is reported. This reaction features high atom economy (100 %), as well as catalyst‐free and gram‐scale conditions. Based on this novel methodology, the total synthesis of hemigossypol, gossypol, and their analogues has been realized. |
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| Keywords: | arenes natural products rearrangements synthetic methods total synthesis |
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