|
|||||
|
|
Metal‐ and Base‐Free Room‐Temperature Amination of Organoboronic Acids with N‐Alkyl Hydroxylamines |
|
| Authors: | Hong‐Bao Sun Liang Gong Yu‐Biao Tian Jin‐Gui Wu Xia Zhang Jie Liu Zhengyan Fu Prof Dawen Niu |
| Institution: | 1. http://www.theniugroup.com;2. State Key Laboratory of Biotherapy and Cancer CenterWest China Hospital;3. School of Chemical Engineering, Sichuan University, Chengdu, China |
| Abstract: | We have found that readily available N‐alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in the presence of trichloroacetonitrile. This amination reaction proceeds rapidly at room temperature and in the absence of added metal or base, it tolerates a remarkable range of functional groups, and it can be used in the late‐stage assembly of two complex units. |
| Keywords: | amination amines boronic acids hydroxylamines trichloroacetonitrile |