| 胰岛素预处理对心肌缺血性损伤的延迟相保护 |
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| 引用本文： | 赵瑛,史姚平,刘楚兵.胰岛素预处理对心肌缺血性损伤的延迟相保护[J].哈尔滨商业大学学报(自然科学版),2008,24(5):518-520. |
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| 作者姓名： | 赵瑛 史姚平 刘楚兵 |
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| 作者单位： | 哈尔滨商业大学,药学院,哈尔滨,150076 |
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| 摘 要： | 探讨胰岛素预处理对大鼠心肌缺血／再灌注（I／R）的延迟相保护作用．健康Wistar大鼠，随机分成假手术组（Sham）、缺血／再灌注组（I／R）、雷米普利组（RMP）、胰岛素低剂量组（INSL）和高剂量组（INSH）．结扎冠状动脉左前降支建立大鼠在体心肌I／R模型，Sham组大鼠穿线不结扎．TTC法观察心肌梗死面积，比色法检测血清乳酸脱氢酶（LDH）和肌酸激酶（CK）的活力．结果显示，I／R组心肌梗死面积大于Sham组（P〈0．01），而RMP、INSL和1NSH组心肌梗死面积低于I／R组（P〈0．01）；I／R组血清LDH活力高于Sham组（P〈0．01），而RMP和INSL组血清LDH活力均低于L／R组（P〈0．01，P〈0．05）；各组血清CK活力无显著性差异．结果表明，胰岛素预处理对大鼠心肌I／R损伤有延迟相保护作用．
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| 关 键 词： | 胰岛素预处理 心肌缺血/再灌注 延迟相保护作用 梗死面积 |
Delayed protection of insulin preconditioning during myocardic ischemia-reperfusion injury in rats |
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| ZHAO Ying,SHI Yao-ping,LIU Chu-bing.Delayed protection of insulin preconditioning during myocardic ischemia-reperfusion injury in rats[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2008,24(5):518-520. |
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| Authors: | ZHAO Ying SHI Yao-ping LIU Chu-bing |
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| Institution: | ZHAO Ying,SHI Yao-ping,LIU Chu-bing (School of Pharmaceutical,Harbin University of Commerce,Harbin 150076,China) |
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| Abstract: | This paper is mainly about the delayed protective effects of insulin preconditioning against myocardial ischemia/reperfusion(I/R) injury in rats.Wistar rats are randomly divided into five groups: Sham,I/R,RMP,INSL and INSH group.The I/R injury is induced by ligation for 30 min and reperfusion for 2 h for every group,while the group of Sham is not ligated.The MIS is observed by TTC method.The activities of LDH and CK in serum are detected through colorimetric method.Myocardial infarction size of I/R group is... |
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| Keywords: | insulin preconditioning myocardic ischemia/reperfusion the delayed protective effects infarction size |
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