Synthesis and characterization of new ointment-like poly(ortho esters) |
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| Authors: | Jiahui Yu Zhengrong LuHua Zheng Renxi Zhuo |
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| Affiliation: | a Department of Chemistry, The Key Laboratory of Biomedical Polymers of the Ministry of Education of China, Wuhan University, Wuhan 430072, China
b Department of Chemical Industry, Wuhan University of Science and Technology, Wuhan 430074, China |
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| Abstract: | Ointment-like poly(ortho esters) were synthesized for the first time from the reaction of 3,9-bis(methylene)-2,4,8,10-tetraoxaspiro[5. 5] undecane with poly(ethylene glycol)-400, N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitamide, respectively. The obtained polymers were characterized by 1H NMR spectra, 13C NMR spectra, elemental analyses, light scattering, and measurements of intrinsic viscosity. The influence of catalyst on the intrinsic viscosity of polymers was investigated. The 9-[(1,3-dihydroxy-2-propoxy) methyl] guanine controlled release profiles of hydrophobic ointment-like polymers such as polymer PII in vitro were also discussed. |
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| Keywords: | Ointment-like poly(ortho esters) Synthesis Characterization Controlled release |
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