| An improved procedure for the synthesis of 4-methylimidazol-2-one |
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| 作者姓名： | Hong Shu Yan Qing Wang Pu Qin Cai Chun Guo |
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| 作者单位： | Hong Shu，Yan Qing Wang，Pu Qin Cai，Chun Guo * School of Pharmaceutical Engineering，Shenyang Pharmaceutical University，Shenyang 110016，China |
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| 摘 要： | A novel one-pot synthetic method of 4-methylimidazol-2-one is described. The target compound is conveniently synthesized from sodium diformylamide, a modified Gabriel reagent prepared, through condensation, hydrolyzation and cyclization reactions without separating intermediates, its total yield is 75.8%.
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| 关 键 词： | 4-甲基咪唑-2-酮 合成 二甲酰胺钠 水解作用 |
| 收稿时间： | 1 March 2007 |
| 修稿时间： | 2007-03-01 |
An improved procedure for the synthesis of 4-methylimidazol-2-one |
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| Hong Shu Yan Qing Wang Pu Qin Cai Chun Guo.An improved procedure for the synthesis of 4-methylimidazol-2-one[J].Chinese Chemical Letters,2007,18(7):777-778. |
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| Authors: | Hong Shu Yan Qing Wang Pu Qin Cai Chun Guo |
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| Institution: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | A novel one-pot synthetic method of 4-methylimidazol-2-one is described. The target compound is conveniently synthesized from sodium diformylamide, a modified Gabriel reagent prepared, through condensation, hydrolyzation and cyclization reactions without separating intermediates, its total yield is 75.8%. |
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| Keywords: | 4-Methylimidazol-2-one Synthesis Sodium diformylamide |
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