Über die Synthese von substituierten 2-Amino-1-pyrrolinen, 1. Mitt.

Three methods for the synthesis of various substituted 2-amino-1-pyrrolines are described:

1. Cyclization of 2.2-disubstituted 4-bromobutyronitriles with ammonia to yield 3.3-disubstituted 2-amino-1-pyrrolines.
2. Reduction of 2-aminopyrrolin-5-ones or 2-iminosuccinimides with LiAlH₄, a route leading especially to 3.3.4-substituted 2-aminopyrrolines.
3. Chlorination of 4.4-disubstituted pyrrolidones with POCl₃ followed by treatment with NH₃ gives 4.4-disubstituted 2-amino-1-pyrrolines.