Facile synthesis of 3-substituted indoles containing highly polarized double bonds |
| |
| Institution: | Department of Chemistry, Yazd University, P.O. Box 89195–741, Yazd, Iran |
| |
| Abstract: | In this paper, an effective procedure is described for the synthesis of novel indoles containing highly polarized double bonds. The strategy involves the preparation of (indolylmethyl)malononitriles via the one-pot three-component reaction of an aldehyde, malononitrile and indole in the presence of Zn(OAc)2/NaOAc under silent and ultrasonic conditions. The reaction further proceeds through oxidative elimination under solvent-free conditions in the presence of Ca(OCl)2 to furnish indolylacrylonitriles in high yields and short reaction times. |
| |
| Keywords: | One-pot Oxidative elimination Indolylacrylonitriles 3-Substituted indoles |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
