Synthesis of C-3' methyl taxotere (docetaxel) |
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| Authors: | Lucatelli Christophe Viton Florian Gimbert Yves Greene Andrew E |
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| Institution: | LEDSS, Université Joseph Fourier, Chimie Recherche, BP 53X, 38041 Grenoble Cedex, France. |
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| Abstract: | Protected (3R,4S)-N-Boc-3-hydroxy-4-methyl-4-phenylazetidin-2-one has been synthesized stereoselectively and used to esterify protected 10-desacetylbaccatin III to give, following removal of the protecting groups, novel C-3' methyl taxotere (docetaxel). |
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