Targeted extraction of active compounds from natural products by molecularly imprinted polymers |
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Authors: | Antonelle Pardo Laetitia Mespouille Philippe Dubois Pierre Duez Bertrand Blankert |
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Institution: | 1.Laboratory of Therapeutic Chemistry and Pharmacognosy, Faculty of Medicine and Pharmacy,University of Mons — UMONS,Mons,Belgium;2.Laboratory of Polymeric and Composite Materials (LPMC), Faculty of Sciences,University of Mons — UMONS,Mons,Belgium;3.Laboratory of Pharmaceutical Analysis, Faculty of Medicine and Pharmacy,University of Mons — UMONS,Mons,Belgium |
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Abstract: | One of the most promising separation techniques that have emerged during the last decade is based on the use of molecularly
imprinted polymers (MIPs). MIPs are stable polymers that possess specific cavities designed for a template molecule, endowed
with excellent selectivity compared to regular solid phase extraction techniques. Molecularly imprinted solid-phase extraction
(MISPE) has already shown a high efficiency for the sample preparation from complex matrices. Natural products received huge
attention in recent years. Indeed, the application of MISPE for the screening of natural products appears extremely interesting
not only for the selective extraction of a target compound but also for the concomitant discovery of new drug candidates,
promising sources of therapeutic benefits. In the present review, examples of recognition and separation of active components
from natural extracts are emphasized. MIPs are very promising materials to mimic the recognition characteristics exhibited
by enzymes or receptors although further developments are necessary to fully exploit their wide potential. |
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