Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae |
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Authors: | Denah M Appelt Maria R Roupas Deana S Way Marcus G Bell Elizabeth V Albert Christine J Hammond Brian J Balin |
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Affiliation: | (1) Department of Neuroscience, Physiology & Pharmacology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA;(2) Department of Pathology, Microbiology & Immunology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA;(3) Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, USA |
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Abstract: | Background Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptotic pathways in both pro- and anti-apoptotic fashions. We have hypothesized that persistent chlamydial infection of neurons may be an important mediator of the characteristic neuropathology observed in AD brains. Chronic and/or persistent infection of neuronal cells with C. pneumoniae in the AD brain may affect apoptosis in cells containing chlamydial inclusions. |
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