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| 无溶剂、无催化剂条件下合成1,4,5,6,7,8-六氢喹啉-5-酮衍生物 | |
| 引用本文： | 荣良策,韩红霞,姜虹,庄启亚,姚昌盛,屠树江.无溶剂、无催化剂条件下合成1,4,5,6,7,8-六氢喹啉-5-酮衍生物[J].有机化学,2008,28(5):837-840. |
| 作者姓名： | 荣良策 韩红霞 姜虹 庄启亚 姚昌盛 屠树江 |
| 作者单位： | 1. 徐州师范大学化学化工学院,徐州221116;江苏省药用植物生物技术重点实验室,徐州221116 2. 徐州师范大学化学化工学院,徐州,221116 3. 江苏省药用植物生物技术重点实验室,徐州,221116 |
| 基金项目： | 国家自然科学基金，徐州师范大学校科研和教改项目，徐州师范大学培育课题基金 |
| 摘 要： | 无溶剂、无催化剂条件, 在NH4OAc存在下以查尔酮和1,3-二酮为原料, 高产率地合成1,4,5,6,7,8-六氢喹啉-5-酮衍生物. 该方法具有反应条件温和、操作简单和环境友好等优点. 并通过IR, 1H NMR, 元素分析和X衍射确证产物的结构. |
| 关 键 词： | 1 3-环己二酮 查尔酮 无溶剂 合成 1 4 5 6 7 8-六氢喹啉-5-酮 |
| 收稿时间： | 2007-6-20 |
| 修稿时间： | 2007-8-24 |
Synthesis of 1,4,5,6,7,8-Hexahydroquinolin-5-one Derivatives under Solvent-Free Conditions without Using Any Catalysts |
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| RONG,Liang-Ce,HAN,Hong-Xia,JIANG,Hong,ZHUANG,Qi-Ya,YAO,Chang-Sheng,TU,Shu-Jiang.Synthesis of 1,4,5,6,7,8-Hexahydroquinolin-5-one Derivatives under Solvent-Free Conditions without Using Any Catalysts[J].Chinese Journal of Organic Chemistry,2008,28(5):837-840. | |
| Authors: | RONG Liang-Ce HAN Hong-Xia JIANG Hong ZHUANG Qi-Ya YAO Chang-Sheng TU Shu-Jiang |
| Institution: | (College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)(Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou 221116) |
| Abstract: | Under solvent-free conditions, synthesis of 1,4,5,6,7,8-hexahydroquinolin-5-one derivatives from chalcones and 1,3-cyclohexanedione in the presence of NH4OAc was carried out in excellent yields without using any catalysts. This method has the advantages of mild reaction conditions, simple protocol, and friendly environment. The structures of the products were confirmed on the basis of IR, 1H NMR spectra, elemental analysis, and that of 3b was additionally confirmed by X-ray diffraction analysis. |
| Keywords: | 1 3-cyclohexanedione chalcone solvent-free synthesis 1 4 5 6 7 8-hexahydroquinolin-4-one |
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