Chromatographic and biological comparison of99mTc-DMSA prepared by direct labelling and ligand exchange reaction |
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| Authors: | J Imre |
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| Institution: | (1) Institute of Isotopes of the Hungarian Academy of Sciences, P. O. Box 77, H-1525 Budapest, Hungary |
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| Abstract: | 99mTc-dimercaptosuccinic acid /DMSA/ is one of the most favourable agents used for renal scintigraphy. This radiopharmaceutical was prepared in two different ways: by direct labelling of tin/II/-dimercaptosuccinic acid and by ligand exchange reaction from99mTc-gluconate at tracer concentration of technetium under acidic condition. The complexes formed were compared using paper chromatography, thin layer chromatography, gel filtration and electrophoresis. Their biodistribution was studied on rats. |
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