Allosteric control of oligonucleotide hybridization by metal-induced cyclization |
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| Authors: | Göritz Mareike Krämer Roland |
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| Affiliation: | Anorganisch-Chemisches Institut, Universit?t Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany. |
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| Abstract: | A bis(terpyridine) modified single-stranded DNA smoothly forms a stable cycle by Fe2+-assisted ring closure. A novel, complex type of allosteric behavior is observed with Zn2+, which reversibly off-regulates binding of a complementary oligonucleotide only in a narrow concentration range. |
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