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Investigation of the interaction between HIV-1 DNA and cyclic peptides by electrospray ionization mass spectrometry |
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| Authors: | Yi Quan Liua Hui Hui Li Yun Hua Yea Gu Yuan a Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry Molecular Engineering of Ministry of Education |
| Affiliation: | [1]Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beifing 100871, China [2]School of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China |
| Abstract: | The interaction between HIV-I DNA and five cyclic peptides (CPI-CP5) was investigated using electrospray ionization mass spectrometry (ESI-MS). It revealed that CPI [c(Ala-Tyr-Leu-Ala-Gly)] and CP4 [c(Pro-D-Tyr-Leu-D-Ala-Gly)] have the higher binding affinity with the duplex DNA among the five cyclic peptides. |
| Keywords: | HIV-I DNA Cyclic peptide ESI-MS |
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