Antioxidant Activity of Phenolic Metabolites from Marine Sponges |
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| Authors: | N. K. Utkina A. E. Makarchenko O. V. Shchelokova M. V. Virovaya |
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| Affiliation: | (1) Pacific Institute of Bioorganic Chemistry, Far-East Division, Russian Academy of Sciences, 690022 Vladivostok, pr. Stoletiya Vladivostoka, 159;(2) Institute of Chemistryand Applied Ecology, Division of Bioorganic Chemistryand Biotechnology, Far-East State University, 690600 Vladivostok, ul. Oktyabr'skaya, 27 |
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| Abstract: | The marine-sponge metabolitesilimaquinone (1), isospongiaquinone(2),puupenone(3), 15-methoxypuupenol (4), 2-methyl-2-pentaprenyl-6-hydroxychromene (5), (+)-curcuphenol (6), (+)-curcudiol (7), and semisynthetic sesquiterpenequinones (8-11) were investigated for ability to trap the free radical 1,1,-diphenyl-2-picrylhydrazyl (DPPH), to inhibit Fe2+ /ascorbate-induced oxidation of lipidsfromrat-brain homogenate, and to inhibit oxidation of linseed oil. It was shown that metabolites 3-5 were the most active antioxidants. |
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| Keywords: | marine metabolites sesquiterpenequinones terpenoid phenols antioxidants marine sponges |
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