Determination of the alpha, beta-adrenoceptor blocker YM-09538 in urine by gas chromatography with a nitrogen-sensitive detector |
| |
Authors: | H Kamimura H Sasaki S Kawamura M Shimizu H Matsumoto Y Kobayashi |
| |
Abstract: | A gas chromatographic method for the quantitative determination of the alpha, beta-adrenoceptor blocker YM-09538 in urine is described. YM-09538 was extracted from alkalinized urine with ethyl acetate and converted to its cyclic methylboronate derivative. Analysis by gas chromatography using a nitrogen-sensitive detector allowed quantitation of the drug over a concentration range of 0.2-5.0 micrograms/ml. Urinary excretion of YM-09538 was determined in humans after oral administration of 50 mg. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|