Copper Catalyzed Synthesis of Thiomorpholine Derivatives: A New Entry of Multicomponent Reaction Between Terminal Alkynes,Isothiocyanates, and Aziridines

Copper acetylide was reacted with isothiocyanate and aziridines to form 1,4‐thiomorpholine derivatives. Reaction outcome depends highly on the reaction conditions and the particular solvent employed. Optimum conditions are developed using copper iodide in hexafluoro‐2‐isopropanol at 60°C. Both the alkyl‐substituted and aryl‐substituted aziridines and terminal alkynes were studied.