Synthesis of Novel 3‐Aryl‐5‐dichloromethyl‐Δ2‐1,2,4‐oxadiazolines |
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Authors: | Antonio Guirado,Jos A. Sandoval,Enrique Alarc n,Marí a Vera,Delia Bautista,Jesú s G lvez |
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Affiliation: | Antonio Guirado,José A. Sandoval,Enrique Alarcón,María Vera,Delia Bautista,Jesús Gálvez |
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Abstract: | The first synthetic approach to hitherto unknown 3‐aryl‐5‐dichloromethyl‐Δ2‐1,2,4‐oxadiazolines, of synthetic and biological interest, has been developed involving high‐yield reactions between N‐(2,2‐dichlorovinyl)benzimidoyl chlorides and hydroxylamine. The molecular structure of one member of this new family of compounds—5‐dichloromethyl‐3‐(4‐fluorophenyl)‐1,2,4‐oxadiazoline—has been determined by X‐ray crystallography. Density functional theory calculations supporting the proposed reaction pathway for the formation of these products have been carried out. |
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