Abstract: | Some new triazole, thiadiazole, oxadiazole, thiazole, oxazole, and imidazole derivatives have been synthesized via the reaction of tramadol bearing a hydrazide, hydrazine carbodithioate, and/or acetic acid group with certain reagents. Molecular docking study had been carried out to demonstrate the reactivity of these synthetic compounds for interaction with Cytochrome P450 2D6 ( CYP2D6 ). |