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3‐(α‐Chlorobenzyl)quinoxalin‐2(1H)‐ones as Versatile Reagents for the Synthesis of 3‐Benzylquinoxalin‐2(1H)‐ones and Thiazolo[3,4‐a]quinoxalin‐4(5H)‐ones |
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| Authors: | Vakhid A Mamedov Nataliya A Zhukova Victor V Syakaev Tat'yana N Beschastnova Milyausha S Kadyrova Anastasiya O Isaeva Sevil V Mamedova Elena L Gavrilova Shamil K Latypov Oleg G Sinyashin |
| Abstract: | Facile and efficient methods for the synthesis of 3‐benzylquinoxalin‐2(1H)‐ones and thiazolo3,4‐a]quinoxalin‐4(5H)‐ones by the reaction of the readily available 3‐(α‐chlorobenzyl)quinoxalin‐2(1H)‐ones and thiourea have been developed, with multiple roles of the latter. Possible mechanisms are discussed. These two‐step sequences can be performed in a one‐pot manner to produce the desired products in moderate to high yields. |
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