| 以烯丙基作为核苷中糖羟基保护基的研究 |
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| 引用本文： | 周英,张亮仁,张礼和.以烯丙基作为核苷中糖羟基保护基的研究[J].高等学校化学学报,1998,19(5):728-731. |
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| 作者姓名： | 周英 张亮仁 张礼和 |
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| 作者单位： | 北京医科大学天然药物及仿生药物国家重点实验室, 北京, 100083 |
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| 摘 要： | 对烯丙基作为核苷糖环上羟基保护基进行了研究.烯丙基可用于核糖羟基的保护,用PdCl2可脱除核苷糖环上烯丙基,保护及脱保护都很简便.PdCl2还可脱除核苷糖环5'-OH常用的保护基--对甲氧基三苯甲基及二对甲氧基三苯甲基.控制适当的条件,PdCl2既能够选择性地脱除对甲氧基三苯甲基或二对甲氧基三苯甲基,又可同时脱除保护糖环羟基的烯丙基.
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| 关 键 词： | 烯丙基 对甲氧基三苯甲基 二对甲氧基三苯甲基 PdCl2 核糖羟基 |
| 收稿时间： | 1997-05-26 |
Studies on the Allyl Protection of Hydroxyl Group in Nucleosides |
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| ZHOU Ying,ZHANG Liang-Ren,ZHANG LiHe.Studies on the Allyl Protection of Hydroxyl Group in Nucleosides[J].Chemical Research In Chinese Universities,1998,19(5):728-731. |
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| Authors: | ZHOU Ying ZHANG Liang-Ren ZHANG LiHe |
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| Institution: | National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing, 100083 |
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| Abstract: | The possibility of allyl as the protection group of the hydroxyls in nucleosides was studied. Allyl bromide can react with thymidine and adenosine in the presence of NaOH to give O allyl protected nucleosides in good yield. PdCl 2 can be used as a reagent for the deprotection. It was found that PdCl 2 can selectively deprotect the p methoxytrityl, di p methoxytrityl or both of the p methoxytrityl, di p methoxytrityl and allyl group. |
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| Keywords: | Allyl p Methoxytrityl Di p methoxytrityl PdCl 2 Hydroxyls of ribose |
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