Syntheses,Structures and Anticancer Activity of NNO‐Tridentate Schiff Base Copper(II) Complexes |
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| Authors: | Rong‐Kai Lin Cho‐Han Hsu Chin‐I Chiu Ying‐Ju Lai a Feng‐Jie Lai Ching‐Ming Chien Chu‐Chieh Lin |
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| Institution: | 1. Department of Chemistry and Center of Nanoscience and Nanotechnology, National Chung Hsing University, Taichung 402, Taiwan, Fax: +886‐4‐22862547;2. Tel: +886‐4‐22840411‐724;3. Department of Dermatology, Chi Mei Medical Center, Tainan 710, Taiwan |
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| Abstract: | A series of heteroleptic copper(II) complexes Cu( R QYMP )(Py]] ( 1a ‐ 4d ) supported on NNO‐tridentate Schiff base ( R QYMP ‐H) and bipyridine (Py=bpy, a ; phen, b ; dpq, c ; dppz, d ) co‐ligands have been synthesized and characterized. X‐ray crystal structural studies of complexes 1b , 2c , 3d and 4a displays that these complexes are mononuclear with a distorted square pyramidal geometry around the copper center. Cytotoxicity results indicate that all of these complexes have much higher activity against HeLa, SCC15, BCC and Ca9‐22 cancer cell lines as compared to cisplatin. Further, copper complex bearing suitable bulky group Schiff base ligands with dppz co‐ligand could be considered in designing efficient metalbased anticancer agents. |
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| Keywords: | Copper complex Schiff base NNO‐tridentate Cell viability |
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