Three‐component One‐pot Synthetic Route to Functionalized N‐Phenyl‐ and N,N‐(1,4‐phenylene)‐2‐alkylimino‐2,3‐dihydrothiazoles under Mild,Solvent‐ and Catalyst‐free Conditions |
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Authors: | Nasir Iravani Mosadegh Keshavarz Maryam Monfared Fatemeh Hosseini |
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Affiliation: | 1. Department of Chemistry, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran;2. Department of Chemistry, Yasouj University, Yasouj, Zip Code 75918‐74831, Iran |
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Abstract: | A simple and efficient one‐pot synthesis of alkyl‐2‐(alkylimino)‐4‐methyl‐3‐phenyl‐2,3‐dihydrothiazole‐5‐carboxylate and dialkyl 3,3′‐(1,4‐phenylene)‐bis‐[2‐(alkylimino)‐4‐methyl‐2,3‐dihydrothiazole‐5‐carboxylate] derivatives from the reaction of phenylisothiocyanate (and also 1,4‐phenylene diisothiocyanate) and primary alkylamines in the presence of 2‐chloro‐1,3‐dicarbonyl compounds is described. This new protocol has several advantages such as lack of necessity of the catalyst and solvent, good yields,mild conditions and short times for reaction. |
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Keywords: | 2‐Chloro‐1,3‐dicarbonyl compounds 2,3‐Dihydrothiazole Phenylisothiocyanate 1,4‐Phenylene diisothiocyanate Primary alkylamines |
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