Synthesis,Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New N‐(Substituted‐thioureido)aminobicyclo Dicarboximide and 3,4‐Disubstituted 1,2,4‐Triazolino‐5‐thione |
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| Authors: | Anna Pachuta‐Stec Urszula Kosikowska Liliana Mazur Marta Swatko‐Ossor Monika Pitucha Anna Malm Gra?yna Ginalskad |
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| Institution: | 1. Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Chod?ki 4a, 20‐093 Lublin, Poland;2. Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Faculty of Pharmacy, Medical University, Chod?ki 1, 20‐093 Lublin, Poland;3. Department of General and Coordination Chemistry, Maria Curie‐Sklodowska University, M. Curie‐Sklodowska 3, 20‐031 Lublin, Poland;4. Department of Biochemistry and Biotechnology, Faculty of Pharmacy, Medical University, Chod?ki 1, 20‐093 Lublin, Poland |
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| Abstract: | The novel N‐(substituted‐thioureido)aminobicyclo dicarboximide and 3,4‐disubstituted 1,2,4‐triazolino‐5‐thione were synthesized and their antimicrobial and antituberculosis activities were examined. Selected dicarboxylic acid anhydrides were used to obtain derivatives of thiosemicarbazide and dicarboximide. Dicarboximides were also cyclized in the presence of an alkaline solution giving 1,2,4‐triazolino‐5‐thione. The chemical structure of all compounds was confirmed by IR, 1H NMR, 13C NMR, the X‐ray crystallography ( 6 , 11 ) and elemental analysis. Antimicrobial and antituberculosis activities of the derivatives were measured. |
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| Keywords: | Dicarboximide Triazole Synthesis Antimicrobial activity Antituberculosis activity |
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