Modulation of DNA binding by reversible metal-controlled molecular reorganizations of scorpiand-like ligands |
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Authors: | Inclán Mario Albelda M Teresa Frías Juan C Blasco Salvador Verdejo Begoña Serena Carolina Salat-Canela Clàudia Díaz Maria Luisa García-España Antonio García-España Enrique |
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Institution: | Instituto de Ciencia Molecular, Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Valencia, Spain. |
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Abstract: | DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed with different experimental techniques provided evidence that pH or metal-driven molecular reorganizations of these ligands regulate their ability to interact with calf thymus DNA (ctDNA) through an intercalative mode. Interestingly enough, metal-driven molecular reorganizations serve to increase or decrease the biological activities of these compounds significantly. |
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