| Direct synthesis of per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives |
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| 引用本文： | CHEN,Jian HU,Chang-MingShanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China. Direct synthesis of per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives[J]. 中国化学, 1995, 13(4): 368-379. DOI: 10.1002/cjoc.19950130413 |
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| 作者姓名： | CHEN Jian HU Chang-MingShanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China |
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| 作者单位： | CHEN，Jian HU，Chang-MingShanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | A convenient and direct per(poly)fluoroalkylmethyl-mtroducing cyclopropanation reaction was described. In the presence of CrCl3/Fe, per(poly)fluoroalkyl iodides reacted with diethyl allylmalonate and its analogs to give per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives in high yields. This reaction was considered to proceed by two steps: radical addition followed by cyclopropanation.
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Direct synthesis of per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives |
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| CHEN,Jian HU,Chang-Ming. Direct synthesis of per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives[J]. Chinese Journal of Chemistry, 1995, 13(4): 368-379. DOI: 10.1002/cjoc.19950130413 |
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| Authors: | CHEN Jian HU Chang-Ming |
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| Affiliation: | CHEN,Jian HU,Chang-MingShanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
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| Abstract: | A convenient and direct per(poly)fluoroalkylmethyl-mtroducing cyclopropanation reaction was described. In the presence of CrCl3/Fe, per(poly)fluoroalkyl iodides reacted with diethyl allylmalonate and its analogs to give per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives in high yields. This reaction was considered to proceed by two steps: radical addition followed by cyclopropanation. |
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| Keywords: | Fluoroalkyl iodide diethyl allylmalonate CrCl3/Fe redox system addition cyclopropanation |
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