Synthesis of E-aryl ethenesulfonamides: a simple one-pot, two-step procedure from 1-hydroxy-1-arylalkanes |
| |
Authors: | Aramini Andrea Cesta Maria C Coniglio Silvia Bijani Christian Colagioia Sandro D'Elia Valerio Allegretti Marcello |
| |
Institution: | Chemistry Department, Dompé Research and Development, Dompé S.p.A., V. Campo di Pile, 67100 L'Aquila, Italy. andrea.aramini@dompe.it |
| |
Abstract: | The unusual reactivity of 1-phenyl-1-ethanesulfonic acid in thionyl chloride was investigated. Mechanistic considerations led us to set up a new and efficient synthesis of E-arylethenesulfonamides starting from 1-hydroxy-1-arylalkanes. The easy availability of the starting materials and the straightforward, one-pot procedure make this process an attractive method for the preparation of these compounds currently largely employed in chemical and pharmaceutical fields. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|