Synthesis,characterization and antimicrobial studies on 13-membered-N6-macrocyclic transition metal complexes containing trimethoprim |
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| Authors: | A.S. Stella Shalini M. Amaladasan N. Prasannabalaji J. Revathi G. Muralitharan |
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| Affiliation: | 1. Postgraduate and Research Department of Chemistry, St. Joseph’s College (Autonomous), Tiruchirappalli 620 002, Tamilnadu, India;2. Department of Microbiology, Centre of Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, Tamilnadu, India |
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| Abstract: | Asymmetrical macrocyclic complexes of MnII, CoII, NiII, CuII and ZnII have been synthesized by the template process using bis(benzil)ethylenediamine as precursor. Bis(benzil)ethylenediamine reacts with transition metal chlorides and trimethoprim in a 1:1:1 molar ratio in methanol to give several solid metal complexes of the general composition [M(L)X2] (M = MnII, CoII, NiII, CuII and ZnII, L = ligand and X = Cl?). They were characterized by physicochemical and spectroscopic techniques. Based on analytical, spectral and magnetic moments, all the complexes are identified as distorted octahedral structures. All the complexes are of the [M(L)X2] type. The shifts of the ν(C![/>N) (azomethine) stretches have been monitored. To find out the donor sites of the ligands, the activity data show that the metal complexes are more potent than the parent ligand. The [M(L)X<sub>2</sub>] complexes showed a broad spectrum of antimicrobial activity <em>in vitro</em> against both gram-positive and gram-negative human pathogenic bacterial isolates and the antimicrobial spectrum enhanced only with a combination of metal chlorides and trimethoprim complex. From the results it is imperative that the synthesized macrocyclic [M(L)X<sub>2</sub>] complexes exhibit potent broad spectrum antibacterial activity.</td>
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| Keywords: | Corresponding author. Tel.: +91 0431 2407082 fax: +91 431 2407045. Trimethoprim Bis(benzil)ethylenediamine Antimicrobial activity Schiff bases |
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