New Cyanoarylporphyrazines with High Sensitivity of Photophysical Parameters to Viscosity as Promising Agents for Photodynamic Therapy |
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Authors: | S A Lermontova T S Lyubova E Yu Ladilina V I Plekhanov I V Balalaeva V P Boyarskii L G Klapshina |
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Abstract: | Photophysical properties and photodynamic activity for a series of cyanoarylporphyrazine pigments have been analyzed depending on the nature of the substituents and their position in the aromatic ring. Replacement of the fluorine atom in the para-position with the methoxy group leads to significant increase in the ratio of the dark and photoinduced cytotoxicities, i.e. potential therapeutic index of porphyrazine as photosensitizer in photodynamic cancer therapy. |
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