Synthesis of functionalized Cu:ZnS nanosystems and its antibacterial potential |
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Authors: | C Chaliha BK Nath PK Verma E Kalita |
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Institution: | 1. Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam 784028, India;2. National Institute of Plant Genome Research, Aruna Asaf Ali Marg, P.O. Box No. 10531, New Delhi 110 067, India |
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Abstract: | Copper doped Zinc Sulfide (Cu:ZnS) nanoparticles were synthesized as potential antibacterial agents, through a solvothermal approach using Mercaptosuccinic acid (MSA) and Sodium citrate (SC) as differential capping agents. Multiple variants of the Cu:ZnS nanoparticles were generated based on the refluxing intervals of the reactions and a choice of the capping agents. The microstructural properties and the elemental composition of the synthesized nanosystems were examined using Scanning Electron Microscopy (SEM) and powder X-ray Diffraction (XRD), along with Energy-Dispersive X-ray spectroscopy (EDX) and Microwave Plasma-Atomic Emission Spectroscopy (MP-AES). The as-synthesized nanosystems were also characterized for their surface attributes using Fourier Transform Infrared spectroscopy (FT-IR), while the optical properties were studied using UV–Vis spectroscopy. The electrostatic stability of the aqueous dispersions of Cu:ZnS was studied as a function of their solvent pH, using Photon Correlation Spectroscopy. For the assessment of the antibacterial properties of the different variants of Cu:ZnS nanosystems, the disk diffusion assay was performed against both Gram-positive and Gram-negative bacteria. The results show a promising antibacterial activity for the Cu:ZnS variants synthesized, with a prominent activity in the email protected]:ZnS nanoparticle making them a novel class of potential antibacterial agents. |
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Keywords: | Corresponding author Tel : +91 3712 275411 Cu:ZnS MSA Sodium citrate Solvothermal ζ potential Antibacterial property |
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