Design and synthesis of novel pyrazol-3ylthiazoles

Biheterocyclic compounds in recent years have gained a significant importance in medicinal chemistry. In this paper the synthesis of novel pyrazol-3ylthiazoles through Vilsmeier–Haack reaction using 2-amino thiazoles as precursors is described. Synthesis of twelve new derivatives was accomplished with moderate yield (70–76%). Structures of all the newly synthesized compounds were characterized by spectral (¹H NMR, ¹³C NMR, IR, LC–MS) and elemental analyses.