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Cobalt‐Catalyzed Cross‐Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides |
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| Authors: | Ferdinand H. Lutter,Lucie Grokenberger,Philipp Spieß ,Jeffrey M. Hammann,Konstantin Karaghiosoff,Paul Knochel |
| Abstract: | A combination of 10 % CoCl2 and 20 % 2,2′‐bipyridine ligands enables cross‐coupling of functionalized primary and secondary alkylzinc reagents with various (hetero)aryl halides. Couplings with 1,3‐ and 1,4‐substituted cycloalkylzinc reagents proceeded diastereoselectively leading to functionalized heterocycles with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides react with primary and secondary alkylzinc reagents providing the alkylated alkynes. |
| Keywords: | catalysis cobalt catalysis cross-coupling diastereoselectivity alkylzinc reagents |