Synthesis and Antimicrobial Activity of Methyl (2 Z )-4-Aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates
and Their Silver Salts |
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Authors: | V L Gein O V Bobrovskaya E A Mashkina V V Novikova R R Makhmudov A N Yankin S E Danilov E A Hvolis V D Belonogova D K Gulyaev |
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Abstract: | A series of new methyl (2Z)-4-aryl-2-{4-(4,6-dimethylpyrimidin-2-yl)-sulfamoyl]phenylamino}-4-oxobut-2-enoates
was synthesized by the reaction of methyl esters of aroylpyruvic acids with
2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in a mixture of acetic
acid–ethanol (1 : 1). The obtained 4-oxobut-2-enoates reacted with silver
nitrate in ethanol–DMF (2 : 1) to form their silver salts. The antimicrobial
activity of the compounds was studied. |
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